![]() Traffic-related air pollution, particulate matter, and autism. Volk HE, Lurmann F, Penfold B, Hertz-Picciotto I, McConnell R. In utero exposure to near-roadway air pollution and autism spectrum disorder in children. 2022 130:17008.Ĭarter SA, Rahman MM, Lin JC, Shu Y-H, Chow T, Yu X, et al. Prenatal exposure to air pollution and autism spectrum disorder: sensitive windows of exposure and sex differences. Rahman MM, Shu Y-H, Chow T, Lurmann FW, Yu X, Martinez MP, et al. Air pollution, neighborhood deprivation, and autism spectrum disorder in the Study to Explore Early Development. McGuinn LA, Windham GC, Messer LC, Di Q, Schwartz J, Croen LA, et al. Maternal experiences with everyday discrimination and infant birth weight: a test of mediators and moderators among young, urban women of color. 2022 601:228–33.Įarnshaw VA, Rosenthal L, Lewis JB, Stasko EC, Tobin JN, Lewis TT, et al. ![]() Air pollution exposure disparities across US population and income groups. Jbaily A, Zhou X, Liu J, Lee T-H, Kamareddine L, Verguet S, et al. Global urban temporal trends in fine particulate matter (PM2♵) and attributable health burdens: estimates from global datasets. Southerland VA, Brauer M, Mohegh A, Hammer MS, van Donkelaar A, Martin RV, et al. These findings demonstrate male-specific changes in the gut-brain axis following DEP/MS and suggest that the gut microbiome is an important modulator of both social behavior and microglia.įuller R, Landrigan PJ, Balakrishnan K, Bathan G, Bose-O’Reilly S, Brauer M, et al. However, while social deficits in DEP/MS males can be reversed by chemogenetic activation of dopamine neurons in the ventral tegmental area, modulation of the gut microbiome does not impact dopamine endpoints. Excitingly, both the DEP/MS-induced social deficits and microglial alterations in males are prevented by shifting the gut microbiome at birth via a cross-fostering procedure. In line with this, we find that the composition of the gut microbiome and the structure of the intestinal epithelium are significantly shifted in DEP/MS-exposed males. Importantly, the gut-brain axis has been implicated in ASD, and both microglia and the dopamine system are sensitive to the composition of the gut microbiome. These behavioral deficits are accompanied by changes in microglial morphology and gene expression as well as decreased dopamine receptor expression and dopaminergic fiber input in the nucleus accumbens (NAc). We demonstrate that combined prenatal exposure to air pollution (diesel exhaust particles, DEP) and maternal stress (MS) in mice induces social behavior deficits only in male offspring, in line with the male bias in autism. Both air pollution and maternal stress during pregnancy have been linked to neurodevelopmental disorders such as autism, but biological mechanisms and targets for therapeutic intervention remain poorly understood. Rather, low-income and minority communities bear the greatest burden, along with higher levels of psychosocial stress. However, toxicant exposures are not equitably distributed. Environmental toxicant exposure, including air pollution, is increasing worldwide.
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